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Gene therapy This novel therapy would deliver genes that produce products or proteins that may not be functioning properly in the penile tissue of men with ED. Replacement of these proteins may result in improvement in erectile function. Experimental animal models have demonstrated improvement in erectile function with gene therapy. Human studies may also demonstrate success with this therapy. Gene therapy may take a long time for regulatory approval and public acceptance. Phetolamine Oral administration of the phetolamine, which blocks the action of adrenaline in the penis (the major inhibitor of erection,Buying Generic Cialis) has been shown to result in erection in men with mild ED. Recently, this drug has received recognition as Vasomax (Schering-Plough, NJ, USA) and has in a number of trials, in men with low-grade ED, been shown to be better than placebo. It has yet to be put before the FDA for final approval and it is unclear if this drug will ever come to the market. Trazodone Trazodone is an anti-depressant with the uncommon side-effect of prolonged erection (priapism,Buying Generic Cialis). This occurs in approximately one in 10,000-20,000 users. Its mechanism of action in promoting erection is not well known, but it is believed that it exerts its primary effect by stimulation of the serotonin receptors in the brain. The medication has been used at the dose of 50-200 mg by mouth each night at bed time (no relationship to intercourse timing). While some studies have cited trazodone’s effectiveness to be as high as 60%, the arrival of Viagra has decreased the use of this medication significantly. The side effects of trazodone include drowsiness in 31%, dry mouth in 1% and fatigue in 19%. At the Sexual Medicine Program at New York Presbyterian Hospital the combination of trazodone and Viagra is not allowed. One study showed that 37% of men improved versus 20% of men who took a placebo.